Primary Pulmonary Hypertension News - Menu Family History May Play a Role in Risk for Obesity A sedentary lifestyle and an unhealthy diet are largely cited as culprits in the ever-increasing numbers of overweight and obese Americans. However, scientists are getting closer to identifying a gene variant that may leave some people more susceptible to obesity. Identification of this gene early in life may help to prevent the onset of significant weight gain and clinical obesity through preventive measures. San Diego, CA (PRWEB) July 19, 2006 –- A sedentary lifestyle and an unhealthy diet are largely cited as culprits in the ever-increasing numbers of overweight and obese Americans. However, scientists are getting closer to identifying a gene variant that may leave some people more susceptible to obesity. Identification of this gene early in life may help to prevent the onset of significant weight gain and clinical obesity through preventive measures. In obese or severely overweight individuals, doctors have long suspected that genetics, in addition to inactivity and poor nutrition, are to blame. To what degree, however, heredity plays a part in weight gain is still unknown. Recognition of an obesity-causing gene, once medically identified, is by no means a quick fix or a way to completely prevent obesity. “As a physician, I have long-known that a family history of obesity is a definite indicator that a person may become severely overweight or clinically obese,” said Eugene Rumsey, M.D., F.A.C.S., surgeon at Pacific Bariatric Surgical Medical Group, Inc. (http://www.pbsmg.com) and Scripps Mercy Hospital in San Diego. “This is true for many other dangerous diseases, such as heart disease, cancer and diabetes, and we must approach the treatment of obesity with the same tenacity.” According to the Centers for Disease Control and Prevention (CDC), 64 percent of all U.S. adults are overweight or obese. Morbid obesity is closely correlated with a number of serious conditions that severely undermines the health of overweight patients, including heart disease, high blood pressure and diabetes. Divided gastric bypass surgery is widely accepted as the most effective surgical weight-loss treatment available and is considered the gold standard to alleviate severe obesity. Surgeons at Pacific Bariatric Surgical Medical Group, Inc. have performed over 9,000 procedures on adult and adolescent patients at Scripps Mercy Hospital. As a result of outstanding aftercare programs and support groups, patients at Pacific Bariatric and Scripps Mercy Hospital see a slightly higher success rate than the national average. Pacific Bariatric Surgical Medical Group, Inc. and Scripps Mercy Hospital are nationally designated by the American Society for Bariatric Surgery as a Center of Excellence for bariatric surgery. Pacific Bariatric Surgical Medical Group, also known as Hillcrest Surgical Medical Group, Inc., has an 80-year tradition of surgical excellence and leadership in San Diego County. Scripps Mercy Hospital has been a health care leader in San Diego County for more than 115 years, offering patients an unparalleled continuum of care. For more information, visit www.pbsmg.com. Established in 1890 by the Sisters of Mercy, Scripps Mercy Hospital serves the San Diego and Chula Vista communities. With 700 licensed beds, more than 3,000 employees and 1,300 physicians, Scripps Mercy Hospital is San Diego’s longest established and only Catholic medical center. With two campuses, Scripps Mercy Hospital is the largest hospital in San Diego County and one of the 10 largest in California. For more information, visit www.scripps.org. ### Press Contact: Kristin Reinhardt New Drug Fights Common Disease Among Premenopausal Women October 9, 2006 - The following is a transcript of a report by medical editor Marilyn Brooks that first aired Oct. 9 2006, on WTAE Channel 4 Action News at 5 p.m. Just about everyone knows someone with high blood pressure or hypertension, but you should also know about primary pulmonary hypertension, which is high pressure in the lungs, and until recently, there hasn't been much help for it. It is a disease that affects 4,000 nationwide, and the numbers are growing. About 400 new cases are discovered every year, 80 percent being premenopausal women. At 73, Madeline Kosky is something of a miracle. Not only because she shows no sign of shortness of breath or fatigue, but because she is alive "I've been blessed, I've been truly blessed," said Kosky. "There's been such a great improvement in Madeline, it's just unbelievable," said Kosky's husband, John. If you could step back in time to August 2001, you would see a different Madeline, sick from primary pulmonary arterial hypertension -- a disease in which pressure rises in the pulmonary artery that connects the right side of the heart to the lungs. High pressures cause shortness of breath and fatigue because the heart works harder to oxygenate the blood. "These symptoms progress over time and eventually, these patients all develop congestive heart failure," said Dr. Srinivas Murali. Eventually, they all die. In 2001, Kosky's life was extended with remodulin, a new drug infused 24 hours a day through a pump in her abdomen. There's a relatively new drug that turned out to be a magic bullet for her though: tracleer. It works by blocking a certain hormone called endothelin, which is found in very large amounts in people who have pulmonary hypertension. Tracleer doesn't work for all of them. Patients vary, and so does the cause of their pulmonary hypertension. If tracleer doesn't work, doctors have others, and more are coming down the pharmaceutical pipeline. "There's days that I forget that I even have it and I say there's nothing wrong with me," said Kosky. There's going to be a conference at the Omni William Penn Hotel on Oct. 14, not only for health professionals and patients, but experts who are coming from all over the country to hear and be heard. For more information on the event, visit www.PAHsymposium.com. |